Here are 37 orthopedic and spine device companies to know.
Note: This list is not comprehensive and arranged in alphabetical order. Orthopedic and spine device companies cannot pay for inclusion of this list.
Please contact Mackenzie Garrity at firstname.lastname@example.org with any questions or comments about this list.
Aesculap Implant Systems (Parkway Center Valley, Pa.). Aesculap Implant Systems is the medical device arm of Aesculap USA focused on orthopedic and spine devices. The company's activL artificial disc is FDA approved for one-level lumbar artificial disc replacement. The activL is the first lumbar artificial disc with a mobile ultra-high molecular weight polyethylene core designed to mimic the movement of a healthy lumbar spine. Aesculap Implant Solutions also provides spinal fusion and minimally invasive spine surgery solutions with the CASPAR Cervical Plate and S4 Element MIS System and developed Plasmapore, an innovative surface enhancing technology that complements the PEEK interbody implant.
Alphatec Spine (Carlsbad, Calif.). Alphatec Spine works with spine surgeons to design and develop products and systems that address the entire spinal fusion procedure. The company developed Arsenal Degenerative, a comprehensive system with ergonomically designed instruments capable of handling complex pathologies from T1 to the pelvis Later this year, the company plans to fully launch the Battalion Lateral System. Alphatec Spine has a large product portfolio including systems for thoracolumbar support, interbody support, cervical support, minimally invasive surgery and biologics.
Amedica Corp. (Salt Lake City). Amedica is a spine and orthopedic device company, specializing in silicon nitride technologies for a variety of medical applications. Silicone nitride is bioactive and compatible across all imaging modalities, offering an alternative to commonly used materials. Amedica is the only FDA registered and ISO 13485 certified nitride medical device manufacturing facility. In 2008, the company first received FDA clearance for their silicon nitride spinal fusion device, Valeo. In addition, Amedica developed Preference 2 Pedicle Screw Systems designed to reduce surgery time and improving surgeon ease of use.
Arthrex (Naples, Fla.). A global medical device company focusing on product development and medical education in orthopedics, Arthrex has developed 11,000 products and surgical procedures to advance minimally invasive orthopedics. Arthrex is dedicated to patient safety and clinical outcomes. The company is developing new technologies with potential multispecialty applications. In 2015 and 2016, FORTUNE listed Arthrex among the 100 Best Companies to Work For.
Aspen Medical Products (Irvine, Calif.). Aspen Medical Products designs, develops and markets upper and lower spinal orthotics. The company was established in June 2000 after International Healthcare Devices, the product development and marketing branch for Aspen Cervical Collars and CTOs, merged with Fiji Manufacturing. Aspen Medical Products was recognized as one of the Best Places to Work in California by OC Business Journal from 2009 to 2015.
Aurora Spine (Carlsbad, Calif). Aurora Spine specializes in minimally invasive regenerative technology.. In 2014, Aurora Spine's ZIP 51, a minimally invasive interspinous fixation implant, received FDA clearance. Surgeons around the world use Aurora's spinal technology, with the first procedure performed in Argentina in August 2017. A month earlier, Aurora received a loan of $350,000 for general corporate purposes.
Bioventus (Durham, N.C.). Bioventus was established in 2012 when the biologics division of Smith & Nephew partnered with Essex Woodlands. Bioventus specializes in orthobiologics and enhancing the natural healing process. Products and services include Bioventus Active Healing therapies and Bioventus Surgical. The company has 660 employees worldwide and generates approximately $250 million in yearly revenue.
Camber Spine Technologies (Wayne, Pa.). Camber Spine Technologies focuses on surgeon designed solutions for minimally invasive and minimally disruptive access to the spine. The company launched its Enza Zero-Profile ALIF devices in July 2016 and a year later surgeons have performed more than 150 procedures using the technology. In Jan. 2017, the company received FDA clearance for its Siconus SI Fusion Screw System, which provides fixation and stabilization of large bones, including the sacrum and ilium.
ChoiceSpine (Knoxville, Tenn.). ChoiceSpine is a privately held spinal implant company located in Knoxville, Tenn. Founded in 2006, Choice offers an extensive array of innovative, surgeon focused systems designed with the best clinical outcomes in mind. In addition, ChoiceSpine offers a full regenerative and osteobiologics portfolio including synthetics, DBM's, structural allograft and amnion allografts. With cutting edge technology in their Veo™ VLIF lateral fusion line to the incorporation of Hydroxyapetite (HA) in their PEEK® interbody systems, ChoiceSpine is committed to always staying ahead of market trends and to provide surgeons with dynamic solutions for their patients.
ConforMIS Corp. (Burlington, Mass.). Founded in 2004, ConforMIS uses iFit image-to-implant technology to develop, manufacture and sell individually sized and shaped joint replacement implants. In recent clinical studies, the company's iTotal CR, the cruciate-retaining total knee replacement implant, showed positive clinical outcomes, including better function and greater patient satisfaction.
DePuy Synthes (Warsaw, Ind.). Part of the Johnson & Johnson family of companies, DePuy Synthes offers various orthopedic and neuro products and services for joint reconstruction, trauma, spine, sports medicine, cranio-maxillofacial, power tools and biomaterials. The company was established in 1895 as Revera DePuy. In 1998, Johnson & Johnson acquired Revera DePuy and later in 2012 the global device company Synthes. Today DePuy Synthes employs approximately 18,000 people across 60 counties, generating $10 billion in annual sales. With its extensive portfolio, the company supports nearly 1 million orthopedic and spine procedures worldwide annually.
DJO Global (Vista, Calif.). DJO Global is an orthopedic device company with products used for surgery, rehabilitation, pain management and physical therapy. Founded in 1978 as DonJoy, DJO Global's first products were neoprene sleeves to pull over joints for support. Smith & Nephew purchased the company for $20 million in 1987, but management bought out the company in 1999 and made it public in 2001. Blackstone Group purchased DJO in 2007 and merged it with Reable Therapeutics. Since then, the company has partnered with several overseas distributors and continues to growth through strategic acquisitions, such as Bell-Horn and Elastic Therapy.
Exactech (Gainesville, Fla.). Founded in 1985 by an orthopedic surgeon and a biomedical engineer, Exactech provides orthopedic implant devices, related surgical instruments and biologic materials and services. The company markets its products in more than 30 markets including the Americas, Europe and the Asian Pacific. In May 2010, Exactech acquired Brighton Partners, the sole-source supplier of the direct compression molded polyethylene bearings used in Exactech's Optetrak knee replacement system, in a $5.5 million all cash deal.
Implanet (Bordeaux, France). Implanted focuses on spine and knee products. The JAZZ Band is the companies latest generation implant, intended to improve the treatment of spinal disorders required for spinal fusion surgery. The company transferred its listing of shares to the Euronext Growth multilateral continuous trading facility from the Euronext regulated market in July 2017, without issuing new shares. The move is expected to simplify administrative burdens and reduce costs. Implanet reported a 19 percent sales growth in the first half of 2017.
K2M (Leesburg, Va.). K2M makes spinal stabilization and minimally invasive systems for treatment of complex spinal pathologies and procedures. Products involve motion preservation, annular repair and nucleus replacement. John Kostuik, MD, its chairman and co-founder, is former chief of spine surgery at Johns Hopkins University School of Medicine. The company is beginning to market its products in Germany, the UK and Japan. The company reported an 11 percent increase in second quarter revnue for 2017, reaching $65.7 million. K2M also signed a long term, exclusive disagreement with Mitsubishi Corp., subsidiary Japan Medicalnext to distribute the company's products in Japan.
Mazor Robotics (Caesarea, Israel). Mazor Robotics develops and manufactures robotic guidance systems for spine and brain surgery. In 2001, the company was founded as M.A.S.O.R Surgical Technologies by Moshe Shoham and Eli Zehavi and renamed Mazor Robotics in 2010. Mazor's first product, SpineAssist, received FDA approval in 2004. In 2016, Mazor launched Mazor X, the next generation spinal robotic system designed to improve pedicle screw placement accuracy. Medtronic purchased 15 systems in a $42 million co-marketing deal.
Medicrea (Rillieux-La-Pape, France). Specializing in digital planning and pre and postoperative analytics, Medicrea has more than 30 FDA approved implant technologies. In total, Medicrea technologies have been used in 100,000 spinal surgeries. The company develops and produces 3D printed titanium implants in France. In June 2017, Medicrea received FDA clearance for the UNiD HUB designed to support surgeon workflow.
Meditech Spine (Atlanta). Meditech Spine designs, develops and distributes spinal implant devices. In September 2016, the company received FDA clearance for the CURE Anterior Cervical Plate System. The system is designed for anterior screw fixation to the C2 to C7 levels of the cervical spine. This year Meditech, in partnership with CURE International, released CURE Lumbar Plating System, allowing surgeons to utilize the lumbar plating system along with Meditech's lumbar Talos fusion devices.
Medtronic (Dublin, Ireland). Formerly based in Minneapolis, Medtronic acquired Covidien in 2015 for $49.9 billion and relocated headquarters to Ireland. The company maintains the Minneapolis-based facility and has promised to add jobs in the U.S.. Medtronic's Infuse bone morphogenetic protein product remains one of the most used synthetic fusion materials in the U.S. The company operates in more than 260 locations in 155-plus countries. In 2016, Medtronic reported $737 million in spine sales, a 1 percent decrease. In total, the company reported $28.8 billion in revenue, a 42 percent increase in 2016.
NuVasive (San Diego). NuVasive develops minimally disruptive and procedurally integrated solutions for spinal surgery. Most well known for the eXtreme Lateral Interbody Fusion lateral access procedure, NuVasive also offers the Maximum Access Surgery platform. With 2,300 employees in over 25 locations worldwide, NuVasive reported $962 million in revenue for 2016. In April 2017, NuVasive launched its Reline Trauma portfolio, allowing for a customized approach to surgery.
Orthalign (Aliso Viejo, Calif.). OrthAlign makes surgical navigation products for precise alignment. Its palm-sized KneeAlign system is a disposable unit for tibial alignment in total knee arthroplasty. KneeAlign is typically lower cost than large console CAS and does not require a CT Scan, MRI or additional x-rays. This past year the company announced its 60,000th joint arthroplasty case and received FDA clearance for its Direct Anterior Approach HipAlign system, which provides surgeons with critical measurements to optimize direct anterior total hip replacements.
Orthofix (Lewisville, Texas). Established in 1980, Orthofix focuses on developing reconstruction and regenerative orthopedic and spine solutions. Orthofix collaborates on research and development with various organizations, including the Musculoskeletal Transplant Foundation, Orthopedic Research and Education Foundation and the Texas Scottish Rite Hospital for Children. The company's strategic business units include BioStim, biologics, extremity fixation and spine fixation.
Osseon Therapeutics (Santa Rosa, Calif.). The University of Northern California founded Osseon Therapeutics as a $14 million startup in 2008. Osseon Therapeutics designs, manufactures and distributes systems to correct vertebral compression factures. The company also focuses on bone cement deliver devices and bone cement composite for treating symptomatic vertebral compression fractures. In Januray 2017, Osseon received a new patent for its Steerable and Curvable Cavity Creation System, which is designed to treat compression spine fractures.
Pacira Pharmaceuticals (Parsippany-Troy Hills, N.J.). Pacira Pharmaceuticals launched Exparel, a bupivacaine liposome injectable suspension indicated for single-does infiltration into the surgical site for postoperative analgesia, in the United States in 2012. In July 2017, the company published a Phase IV study in the Journal of Arthroplasty showing Exparel reduced patient pain after total knee arthroplasty from 12 to 48 hours after surgery, and the company achieved statistical significance in reducing opioid consumption. In the second quarter of 2017, Exparel net product sales reached $69.8 million, up 6 percent over the same period last year.
Paradigm Spine (New York City). Established in 2005, Paradigm Spine specializes in non-fusion spinal procedures for patients with spinal stenosis. In 2012, the company's coflex Interlaminar Stabilization device received FDA clearance. In January 2016, a a five-year study published in the International Journal of Spine Surgery found interlaminar stabilization is an effective and sustainable treatment for spinal stenosis patietns, and wasn't necessarily a precursor to fusion. Paradigm Spine also commissioned a Miliman study into the economic value of colfex and found cost reduction when compared with primary lumbar fusion.
RTI Surgical (Alachua, Fla.). RTI Surgical provides surgeons with biologic, metal and synthetic implants. The implants are used in sports medicine, general surgery, spine, orthopedic, trauma and cardiothoracic procedures. In June 2017, RTI Surgical partnered with Advanced Regenerative Manufacturing Institute, a public-private manufacturer which brings together nearly 100 partner organizations to develop processes and technologies for cells, tissues and organs.
SeaSpine (Carlsbad, Calif.). Founded in 2002, SeaSpine develops and manufactures orthobiologics and spine fusion devices. Partnering with physicians around the world, SeaSpine is dedicated to developing effective spinal solutions to restore mobility and improve quality of life in patients with spine diseases. From 2007 to 2015, the spine device developer merged with Integra. Then in 2015, Integra spine's business launched SeaSpine as an independent company. Most recently, SeaSpine launched the Shoreline Anterior Cervical Standalone System, designed to improve implant placement and plate fixation.
SI-Bone (Cupertino, Calif.). A spin-off company created after Wright Medical bought INBONE Technology, SI-Bone was established in April 2008. SI-Bone specializes in minimally invasive sacroiliac joint replacements. The company's iFuse Implant System uses titanium implant technology for sacroiliac fusion. More than 1,000 surgeons have performed more than 25,000 procedures with SI-Bone's iFuse implant system. Around 50 journal articles and publications support the use of iFuse. In January 2017, SI-Bone launched a warranty program for iFuse to guarantee results of the procedure.
Smith & Nephew (London, England). Smith & Nephew develops products and services for orthopedic reconstruction, wound management, sports medicine, trauma and extremities. In 2016, the company reported annual sales of $4.6 billion and closed a $275 million acquisition of Blue Belt Technologies' Navio robotic-assisted surgery system. In June 2017, Smith & Nephew released the Navio application for total knee replacements, supporting the Journey II, Legiona Primary and Genesis II Total Knee Systems.
SpineGuard (St. Mande, France). Founded in 2009, SpineGuard develops spine devices through its Dynamic Surgical Guidance platform in partnership with medical device companies. This technology helps surgeons treating spinal instabilities and deformities. SpineGuard's PediGuard device has been used during 55,000 pedicle screw placement procedures worldwide. In January 2017, the company received FDA clearance to market the Dynamic Surgical Guidance in combination with Zavation's spinal fusion system.
Stryker Corp. (Kalamazoo, Mich.). Stryker is a seasoned player covering all key applications of hip, knee, upper Founded in 1941, extremity and spinal implants. Since 2013, Stryker has made a slew of acquisitions including MAKO Surgical for $1.65 billion, Trauson for $764 million, Small Bone Innovations for $375 million, Physio-Control for $1.28 billion and most recently Novadaq Technologies for $701 million. In 2016, Stryker reached $11.3 billion in sales and reported 33,000 employees globally.
Titan Spine (Mequon, Wis.). Founded in 2006, Titan Spine focuses on titanium implants for spinal fusion procedures. The company's revolutionary surface technology promotes fusions. In 2017, Titan Spine reported the nanoLOCK Endoskeleton interbody fusion device was use in its 1,000 surgeries. The company offers a one-time free replacement warranty on Endosekelton devices. In the second quarter of 207, Titan Spine reported nanoLOCK sales volume increased 42 percent over the first quarter and has achieved 2,500 implantations since launching in October 2016.
TranS1 (Wilmington, N.C.). TranS1 develops products to solve spinal pathologies while minimizing trauma to the tissues surrounding the spine. The products are designed to build a foundation upon the L5-S1 joint. Currently, TranS1 is participating in 85 studies to research the safety and efficacy of AxiaLIF+ for spinal fusion at the L5-S1 joint. In 2016 the company was recognized as the Most Innovative Workplace in Denver and was a finalist for the Technology Association's Apex Awards. In 2017, TranS1 launched its Capital Bone Graft Harvester. The new technology is designed for fast, reliable and reproducible harvesting of autograft material from the iliac crest.
Vertiflex (San Clemente, Calif.). In 2015, Vertiflex received FDA clearance for its Superion Interspinous Spacer System. Superion is designed from moderate lumbar spinal stenosis and to be a minimally invasive motion preserving device. Vertiflex is devoted to providing advanced and minimally invasive treatments for lumbar stenosis. The company's Totalis Direct Decompression System is designed to safely perform minimally invasive direct decompressions of the lumbar spine.
Wright Medical Technology (Arlington, Tenn.). Wright Medical Technology specializes in developing products and instruments for different areas of orthopedics, including upper extremities, lower extremities and biologics. The company's products aim to alleviate pain and restore lifestyles and are available in more than 60 countries. Wright completed its acquisition of BioMimetic Therapeutics in 2013 for $42.5 million. That same year, Wright acquired French orthopedic extremities company Biotech International for $75 million.
Zimmer Biomet (Warsaw, Ind.). Zimmer and Biomet were both considered orthopedic device company giants when they merged in June 2015 to create Zimmer Biomet in a $14 billion transaction. In 2016, the combined company acquired LDR Spine, the maker of Mobi C and L artificial discs, for $1 billion and Medtech, which developed the ROSA robotic system for brain and spine surgery for around $132 million. Zimmer Biomet operates in 25 countries around the world and sells products in more than 100 counties. The Progress IV clinical trial evaluates the safety and clinical effectiveness of autologous protein solutions, prepared from a small sample of a patient’s own blood with an investigational device called the nSTRIDE APS Kit, on pain and function associated with knee osteoarthritis.
Zyga Technologies (Minnetonka, Minn.). Zyga was founded in 2008 to develop technology for resurfacing the fact joint. In 2009 the company centered its focus on developing products for minimally invasive surgery to fuse the sacroiliac joint. The SImmetry Sacroiliac Joint Fusion System is a minimally invasive spine surgery procedure designed to help stabilize the SI joint. Zyga also developed its Glyder Facet Restoration Device. The device is intended to provide relief from lumbar facet pain, restoring fact joint function while preserving anatomy. Earlier this year, Zyga announced its 100th patient to enroll in the EVoluSIon clinical study. The clinical study evaluates long term fusion and pain reduction in patients receiving SImmetry Sacroiliac Joint Fusion.