How patient characteristics affect rhBMP-2 spinal fusions: 5 key notes

Spine

A new study published in Spine examines how human characteristics affect outcomes for spinal fusion using bone morphogenetic protein-2.

 

The study uses data from the Yale Open Data Access Project which included 10 industry-sponsored randomized controlled trials of rhBMP-2. The researchers found:

1. Primary support for rhBMP-2 improving outcomes for patients in these categories:

· Smokers
· Younger patients under 60 years old
· Normal weight patients

2. The rhBMP-2 wasn’t associated with improved outcomes for patients in these groups:

· Non-smokers
· Patients older than 60 years old
· Obese
· Severely obese

3. There were decreased harms in patients without previous back surgery associated with rhBMP-2. However, patients who had previous spinal surgeries didn’t see the same improvements.

4. The researchers concluded patient characteristics could have an impact on outcomes for spinal fusions with rhBMP-2.

5. The study authors recommended additional research into the subgroups associated with better outcomes to identify patients who are most likely to benefit.

More articles on spine surgery:
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Prestige LP cervical arthroplasty vs. spinal fusion: 6 key notes on 7-year data

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