Canada-based Krembil Research Institute researchers studied which biomarkers play a role in spine osteoarthritis development, according to Medical Xpress.
The study included tissue biopsies from 55 patients who had decompression or discectomy at Krembil Neuroscience Centre at Toronto Western Hospital. Researchers analyzed the "role, function and signaling mechanisms of two tissue biomarkers: microRNA-181a-5p and microRNA-4454," according to Medical Xpress.
The Journal of Clinical Investigation Insight published the study.
Here are five observations:
1. The study revealed two tissue biomarkers that, when elevated, create inflammation, cartilage destruction and collagen depletion.
2. The researchers concluded measuring the levels of microRNA-181a-5p and microRNA-4454 may assist providers in pinpointing the state of disease progression.
3. These biomarkers also reveal the severity of cartilage destruction.
4. Further research involves determining whether the biomarkers are noticeable in blood.
5. The researchers hope their discovery will assist in developing a way to stop and reverse spine degeneration.