UCSF’s Dr. Alfred Kuo Develops Cell-Based Treamtents for Orthopedics

Alfred Kuo, MD, assistant professor of orthopedic surgery at University of California in San Francisco, has been working with a team of researchers on studies examining the use of cell-based therapies for orthopedic treatment, according to an AAOS Now report.

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The researchers are comparing the relative ability of three types of stimuli to reduce chondrogenesis in mesenchymal stem cells as well as the progenitors of chondrocytes and osteoblasts. During their research, the team developed a model system of articular cartilage-stimulated chondrogenesis using human mesenchymal stem cells and bovine cartilage, according to the report.

Dr. Kuo has received the Clinician Scientist Award for this research. “If we know how things work, we can identify the signaling pathways in the process, eventually we may be able to enhance articular chondrogenesis, thereby improving the equality and quantity of repair tissues,” he said in the report. “You might imagine that if we had the proper mixture factors, we could improve the results of current surgical procedures to treat cartilage injury.”

Read the report on stem cell-based research.

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