The study assessed data on 88,830 total knee arthroplasties performed with a peripheral nerve block between 2013 to 2016; liposomal bupivacaine was used as part of a multimodal approach to manage postsurgical pain in 18,817 patients.
Liposomal bupivacaine use was not associated with a clinically meaningful reduction in inpatient opioid prescription and length of stay. It had no effect on the cost of hospitalization.
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