Using handheld computers, 120 patients with knee osteoarthritis reported on their pain three times a day during 22 days. Patients also wore an accelerometer to capture daily physical activity.
Here are four points:
1. Patients with two copies of the Asn40 allele of mu-opioid receptor had the greatest day-to-day pain variability.
2. Patients with the Val/Val genotype of catechol-O-methyltransferase had the greatest pain variability, as well as the greatest increase in pain as a result in physical activity.
3. Consistencies were found between a similar pattern of findings across bi-directional lags with a negative feedback loop between daily physical activity and pain according to genotype.
4. Results showed no significant between-person differences for daily pain when comparing patients to catechol-O-methyltransferase or mu-opioid receptor.
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