NanoFuse bioactive glass–demineralized bone matrix composite was found to be stronger than DBM alone or bioactive glass alone, according to a study in the International Journal of Spine Surgery.
Researchers examined whether combining DBM and bioactive glass could produce a synergistic osteoinductive effect beyond the materials alone. They used an in vitro C2C12 alkaline phosphatase assay to assess osteogenic differentiation following exposure to BMP-2 and test materials.
The results found that NanoFuse composite had greater alkaline phosphatase activity compared to the materials alone.
“The goal of this study was to understand biology—not to make commercial comparisons,” Kingsley Chin, MD, an author on the study said in a Jan. 27 news release. “BMP-2 served as a control to help contextualize osteogenic signaling. What the data clearly show is that combining bioactive glass with DBM produces a stronger and more consistent early osteoinductive response than either material alone. That insight is highly relevant as spine surgery continues to evolve toward safer, more efficient biologic solutions.”
