Platelet-rich plasma and hyaluronic acid injections are the most established biologics-based treatments for knee osteoarthritis so far, said Dr. Mandelbaum. “It’s too early yet to make confident use of stem cells or amniotic fluid, and we must warn patients to be particularly careful about claims for these substances,” he wrote.
“But eventually, I believe the science will triumph over quackery and orthobiologics will become an essential part of every knee surgeon’s armamentarium,” he said. Dr. Mandelbaum outlined available orthobiologics, which include:
- Glucosamine-chondroitin sulfate
- Hyaluronic acid
- Platelet-rich plasma
- Cytokine modulation
- Stem cells
- Amniotic fluid
More articles on biologics:
FDA warns Genetech for manufacturing unapproved orthobiologic products that may have led to infection — 9 insights
Toward a more robust regulatory pathway — 3 Qs with Carmell Therapeutics’ CEO Randy Hubbell
Gene therapy may be more cost effective for spinal muscular atrophy: 7 details
