New York City-based NYU Grossman School of Medicine researchers will lead a seven-year clinical trial examining whether low-dose ketamine can improve pain control after surgery for serious orthopedic injuries.
The study has been approved for $19.67 million in funding from the Patient-Centered Outcomes Research Institute. The multicenter trial, called Ketamine for Pain After Orthopedic Surgery for Trauma, is expected to enroll 1,800 patients undergoing surgery to repair broken bones, according to an Aug. 25 news release.
Participants will receive either standard pain treatment alone or standard treatment plus a low-dose ketamine infusion during and after surgery. Researchers will track pain severity and its effect on daily life and examine mental health and recovery.
Jing Wang, MD, PhD, Philipp Leucht, MD, PhD, and Andrea Troxel, ScD, are leading the study. The trial is NYU Grossman School of Medicine’s first award through PCORI’s Phased Large Awards for Comparative Effectiveness Research program.
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