The clinical benefit of demineralized bone in stimulating bone formation was introduced by Marshall Urist and is well studied. Demineralized bone forms a natural osteoconductive and osteoinductive scaffold, which promotes the migration of cells and the differentiation into osteoblasts that mineralize the matrix.
Theoretically, a vacuum infusion packaging system could provide provide better cell distribution, viability and functionality post seeding.
Testing was conducted using Profuse Bioscaffold, a three dimensional scaffold of demineralized cancellous bone, packaged under a patented system called Vacuum Infusion Packaging (VIP), and two other similar, demineralized products in non vacuum packaging.
SEM imaging illustrated considerable differences in MSC migration, adhesion and functional cell cluster characteristics between vacuum and non-vacuum packaging.
These results suggest that 3D ProFuse Bioscaffold in VIP ensures homogenous distribution of cells— therefore promoting better cell migration, integration and functionality to the demineralized bone interface.
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