Researchers found elevated levels of citrullinated proteins and levels of the enzymes (PAD2 and 4) in the knees of those with rheumatoid arthritis. Treatment with methotrexate, an anti-rheumatic drug, had no effect on the levels of CP or PAD. However a single injection of glucocorticoid reduced both the level of protein citrullination and PAD4. Researchers also found a decrease in visible signs of inflammation after the injection.
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