The previous recommendations were made in 2009, and the guidelines are largely unchanged. They were developed to include only treatments which are less invasive than knee replacement surgery.
The first update for the 2013 guideline reduces the recommended dosage of acetaminophen from 4,000 mg to 3,000 mg per day. This is an overall change made by the FDA since 2009 for acetaminophen use.
Additionally, the guidelines no longer recommend intra-articular hyaluronic acid as a method of treatment for patients with symptomatic osteoarthritis of the knee. In 2009, this method was reviewed as inconclusive.
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