PRP Could Enhance Healing in Nonunion Long-Bone Fractures

Written by  Laura Dyrda | Tuesday, 21 February 2012 21:08
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A recent study conducted in India showed that platelet-rich plasma can enhance the rate of union among patients with non-united long bone fractures, according to an AAOS Now report.
The study examined 60 patients with tibia, femur, humerus and radius long-bone fractures. There were 42 patients who underwent an open reduction and internal fixation while the remaining 18 patients were treated with closed reduction and internal fixation, according to the report. All patients received 20 mL to 30 mL of PRP at the nonunion site an average of 9.1 months after the injury.

The researchers found:
•    55 patients reported a callus formation after eight weeks
•    40 patients reported bridging trabeculae after 12 weeks
•    55 patients had fracture union by 24 weeks
•    When the fracture united, patients received the injection two to four months after the diagnosis of nonunion
•    Among the five patients with fractures that failed to unite after PRP, the injection was administered 12 months or more after the original nonunion diagnosis.

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