Researchers studied the binding of BBP with four growth factors from the transforming growth factor –beta family using surface Plasmon resonance and found that BBP bound all four growth factors with an intermediate affinity.
While the retention of rhBMP-2 alone ranged from 40 percent on the first day to 30 percent on the seventh day, the presence of BBP increased the retention of rhBMP-2 from 85 percent on the first day to 55 percent on the seventh day. The collagen sponge implants with BBP resulted in significantly greater fusion rates than those employing the BMP alone.
Researchers concluded that the mechanism of BBP enhanced the osteoinductive properties of BMPs involved in the binding and retention of the growth fracture, resulting in longer exposure of BMP to the fusion site.
Read the abstract about fusions combining BBP with BMP.
Read other coverage on BMP use:
– Medicare Advisory Committee Votes Against Off-Label BMP Use
– Study: 85% of BMP Procedures Between 2002 and 2007 Used for Off-Label Applications
– Spine Surgery Research Update: Treatment of Cervical Spine
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