A rare subtype of neuron from transplanted stem cells can reconnect spinal motor circuits and activate leg muscles after injury, offering new insight for spinal cord repair strategies, according to a study published in Nature Communications.
Researchers at College Station-based Texas A&M University transplanted neural progenitor cells into injured spinal cords in animal models. In 20% to 30% of test subjects, a small population of graft-derived interneurons integrated with spinal motor networks and, when activated, triggered leg muscle activity, functional evidence that these cells can form new connections within the spinal cord, according to a March 30 news release.
The study, led by Jennifer Dulin, PhD, identified the specific neuron types capable of reactivating locomotor pathways, a key step in refining stem cell therapies for spinal cord injury. Researchers also emphasized the need for activity-based rehabilitation to help newly integrated neurons adapt and function effectively within damaged spinal circuits.
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