Nature Neuroscience published the study online on April 18.
Here are seven observations:
1. SCI higher than thoracic level 5 cause autonomic nervous system circuitry, impacting bodily functions like breathing, heartbeat and digestion.
2. The researchers found abnormal nervous system circuitry begins to form as the body reacts to SCI. Ultimately, this activates an anti-inflammatory and immune suppressive reflex.
3. Patients with high-level SCI often experience severe complications from common infections.
4. The researchers tested chemogenetic agents in mouse models to find a treatment. Chemogenetics possess the ability to exert selective pharmacologic control over cell-signaling processes.
5. In the mouse models, the researchers used chemogenetics to stop signaling transmission from interneurons that trigger the immune suppression reflex.
6. The researchers successfully controlled the neurons because the forming nerves had specific genetic signatures. They reversed the immune suppressive reflex.
7. The researchers reported they are years away from human trials.
More articles on spine:
4 thoughts on Barrow Brain and Spine’s neurosurgery technology
Cervical spinal fusions — How does the number of fused levels affect quality of life? 5 key notes
St. Elizabeth spine specialists present on back pain — 4 takeaways
At the Becker’s 32nd Annual Meeting: The Business and Operations of ASCs, taking place October 29-31 in Chicago, ASC leaders, surgeons and healthcare executives will explore strategies to drive growth, enhance operational performance, navigate reimbursement challenges and prepare for the future of ambulatory surgery. Apply for complimentary registration now.