The notochord represents the first formation of the nervous system, eventually turning into the cushion between the spine’s vertebrae.
Here are five takeaways:
1. The researchers looked at DNA regions that switched on gene expression in the notochord, called notochord cis-regulatory modules.
2. This study is relevant to spine research because the notochord fragments can create back pain if they move.
3. The team analyzed marine organism Ciona, as human notochord CRMs have not yet been characterized.
4. Their findings revealed the notochord CRMs have DNA sequences bound by transcription factors, which turn on gene expression.
5. The team wants to now use these findings in the context of the human genome.
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