Spinal fusion with stem cells vs. BMP: 4 key findings

Written by Laura Dyrda | March 31, 2019 | Print  |

A study published in the February 2019 issue of the International Journal of Spine Surgery compares fusion rates between rhBMP-2 and mesenchymal stem cells for minimally invasive transforaminal lumbar interbody fusion.

The study authors examined patients who underwent surgery performed by a single surgery and compared the fusion rate between patients who had rhBMP-2 or cellularized bone matrix to promote fusion. The researchers included data from 78 patients in the retrospective review, with 39 who received rhBMP-2 and 39 who received CBM.

Four key points:

1. The CBM group reported a 68 percent fusion rate, compared to 78 percent in the rhBMP-2 group.

2. Hypertension was a predictor of radiographic non-union, and among the seven smokers spread between the two groups, one from each group reported pseudarthrosis.

3. Three patients in the CBM group required revision as a result of symptomatic pseudarthrosis, compared to one patient in the rhBMP-2 group.

4. The study authors concluded no significant differences in fusion rates or revision rates for patients in both groups.

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