Jagged-1 protein could promote bone regeneration, study finds: 5 insights

Written by Shayna Korol | February 05, 2018 | Print  |

Temporary and localized delivery of the protein Jagged-1 promotes bone regeneration in rodents, according to a study in NPJ Regenerative Medicine.

Here are five things to know:


1. Every year, 33 percent of Americans suffer from a musculoskeletal condition that requires medical intervention. Direct medical costs approach $1 trillion annually. Despite the frequency of skeletal dysfunction, there are limited safe and effective bone growth factors in clinical use.


2. Notch is a cell-cell communication pathway that regulates self-renewal and differentiation within the mesenchymal/osteoblast lineage. Jagged-1 is the principal Notch ligand in bone.


3. Jagged-1 is an osteoinductive protein that positively regulates posttraumatic bone healing in animals and is a bone-anabolic agent with therapeutic potential for regenerating traumatic or congenital bone defects.


4. Notch gain-of-function using recombinant Jagged-1 protein on collagen scaffolds encourages the healing of craniofacial and appendicular surgical defects in mice and rats.


5. Localized delivery of Jagged-1 promotes bone apposition and defect healing and avoids the diffuse bone hypertrophy characteristic of the clinically problematic bone morphogenetic proteins.


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