The 10 largest orthopedic device companies

Stryker is the largest orthopedic device company in the world, with a current annual revenue of $18.4 billion, up 7.8 percent from the previous year, according to an Aug. 16 report from Mass Device. 

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The 10 largest orthopedic device companies based on annual revenue: 

1. Stryker (Kalamazoo, Mich.): $18.4 billion 

2. Johnson & Johnson-DePuy Synthes (multiple headquarters): $8.6 billion 

3. Zimmer Biomet (Warsaw, Ind.): $6.9 billion 

4. Medtronic (multiple headquarters): $4.5 billion 

5. Smith + Nephew (London): $3.6 billion 

6. Enovis (Wilmington, Del.): $1.6 billion 

7. NuVasive (San Diego): $1.2 billion 

8. Globus Medical (Audubon, Pa.): $1 billion 

9. Orthofix (Westminster, Colo.): $698 million 

10. ZimVie (Lewisville, Texas): $450 million

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