Target stem cells to stop osteoarthritis progression, study suggests: 3 insights

Written by Shayna Korol | May 14, 2018 | Print  |

Osteoarthritis-mesenchymal stem cells may drive cartilage degeneration pathogenesis and should be targeted in osteoarthritis therapy, according to a study in Scientific Reports.

Here are three things to know.

1. According to the Arthritis Foundation, over 50 million Americans suffer from arthritis, making it the leading cause of disability in the U.S.

2. The researchers took OA-MSCs from 61 male patients and 69 female patients undergoing total knee replacement surgery to generate multiple cell lines.

3. The study authors found that two mesenchymal stem cell populations exist in human OA cartilage. The findings suggest it may be beneficial to inhibit the activation of OA cartilage-derived stem cells as a way to prevent OA progression.

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