NIH awards grant for boosting bone integration of orthopedic devices — 6 notes

Biologics

National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Numerate a grant.

Here are six notes:

 

1. Numerate is a computational drug design company leveraging artificial intelligence at cloud scale.

 

2. The grant is intended for Numerate to enhance outcomes for patients undergoing orthopedic implant surgery.

 

3. Uwe Klein, PhD, Numerate's vice president of biology, will serve as principal investigator alongside co- investigator Andre J. van Wijnen, PhD, professor of biochemistry, molecular biology and orthopedic surgery at Rochester, Minn.-based Mayo Clinic.

 

4. The grant will go toward the project, "EZH2 inhibitors as endoprosthetic device coatings that induce osteogenesis and promote implant osseointegration."

 

5. Dr. van Wijnen's lab has already found the epigenetic enzyme 'Enhancer of Zeste homolog 2,' or EZH2, plays a role in skeletal development and osteoblast differentiation. The researchers found inhibiting EZH2 yields "stimulation of new bone formation by activation of the osteogenic pathway in mesenchymal stem cells."

 

6. The hypothesis is that coating orthopedic implants with these compounds will help with integrating the bone and the implant.

 

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