10% of Pediatric Spine Fusion Cases Include Off-Label BMP Use

Off-label use of bone morphogenetic protein is applied in nearly one in 10 pediatric spinal fusion procedures, according to research published in The Journal of the American Medical Association and reported by MedPage Today.

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For the study, researchers analyzed data from the Kids’ Inpatient Database. The use of BMP has sparked controversy since its introduction in 2002, with some clinical research suggesting its use in adults is associated with wound dehiscence, spinal stenosis and respiratory stenosis. Orthopedic device giant Medtronic, which manufactures and markets BMP-product InFuse, has funded research that helped bring BMP into the marketplace.

The U.S. Senate Finance Committee is currently investigating financial relationships between Medtronic and physicians who conducted and published positive research results of BMP.

Researchers found that 9.2 percent of pediatric spinal fusion procedures use BMP, which was also shown to add as much as $4,000 to each case.

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