The researchers developed a chronically implanted spinal chamber suitable for time-lapse in vivo multiphoton microscopy without the need for repeat surgical procedures. The procedure derived from routine, repeated images of mice over five postoperative weeks during 10 separate imaging sessions.
During development, neither motor-function deficits nor neuropathology in the spinal cord resulted from the chamber implantation. Massive microglia infiltration within 1 d along with a heterogeneous dieback of axon stumps were observed after a laser-induce spinal cord lesion.
According to the article, the researchers’ method offers a platform for understanding cellular dynamics in response to injury and therapeutic interventions.
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