4 key notes on placebos in spine clinical trials

A study published in The Spine Journal examines placebos used during lumbar and pelvic joint thrust manipulation clinical trials.

Advertisement

The researchers included data from the Medline, Embase, Cochrane Central Register of Controlled Trials, Index to Chiropractic Literature and relevant bibliographies to gather data. The studies included were randomized, placebo/sham-controlled trials. There were two independent reviewers who assessed the study quality and data for 25 trials included in the study.

 

The researchers found:

 

1. Eighteen trials included sham manual spinal manipulation therapy for the placebo control. The most common way to approach the SMT was with the SMT set-up, but without applying any thrust.

 

2. Two studies used a validated insert a priori placebo.

 

3. Eight studies highlighted the success of subject blinding. However, the researchers found “strong potential” for unmasking control subjects due to imperfect placebos.

 

4. The study authors recommended further trials include an assessment of the subject blinding to determine whether it was successful.

 

More articles on spine surgery:
Artificial cervical disc replacement for two-level disease
5 things to know about OLIF: Does it solve traditional spinal fusion’s challenges?
15 spine surgeons discuss techniques revolutionizing spine care

At the Becker's 23rd Annual Spine, Orthopedic and Pain Management-Driven ASC + The Future of Spine Conference, taking place June 11-13 in Chicago, spine surgeons, orthopedic leaders and ASC executives will come together to explore minimally invasive techniques, ASC growth strategies and innovations shaping the future of outpatient spine care. Apply for complimentary registration now.

Advertisement

Next Up in Spine

Advertisement

Comments are closed.