The study authors examined 502 consecutive adult patients who received a high dosage, on average 115 mg, of rhBMP-2, for complex spinal procedures. There were 265 primary and 237 revision procedures with 261 patients receiving an interbody device. There was an average of 11.5 vertebrae instrumented.
The researchers found:
• Interoperative complication rate of 8.2 percent
• Major medical perioperative complication rate of 11.6 percent
• Major perioperative surgical complication rate of 11.6 percent
• Minor medical complication rate of 18.9 percent
• Minor surgical complication rate of 2.6 percent.
• Cancer prevalence of 3.4 percent but no correlation between increasing rhBMP-2 dosage and cancer, radiculopathy or seroma.
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