Platelet-rich plasma can enhance ACL cell viability and function in vitro, according to a study published in The Journal of Bone and Joint Surgery.
For the study, researchers obtained fresh blood and ACL remnants from four patients undergoing ACL reconstruction surgery. Platelet-poor plasma and platelet-rich plasma were prepared from the samples with various growths concentration factors.
Researchers found that the concentration of the main growth factors were higher in the platelet-rich clot than the platelet-poor clot. The in vitro treatment of ACL cells with platelet-rich clot releasate resulted in a significant increase in cell number, and the total collagen production by the platelet-rich clot releasate-treated cells was significantly higher because of the enhanced cell proliferation.
There was no significant effect of the platelet-rich clot releasate treatment on gene expression for type-I collagen. However, type-III collagen was significantly enhanced, according to the report.
Read the abstract for "Effects of Autologous Platelet-Rich Plasma on Cell Viability and Collagen Synthesis in Injured Human Anterior Cruciate Ligament."
Read other coverage on sports medicine studies:
- Study Shows ACI Treatment Outcomes Similar Between Older and Younger Patients
- Study: Osteochondral Grafts May Be Safe for Young Knee Replacement Patients
- Study: PRFM Makes Little Long-Term Difference When Performing Arthroscopic Rotator Cuff Repair
For the study, researchers obtained fresh blood and ACL remnants from four patients undergoing ACL reconstruction surgery. Platelet-poor plasma and platelet-rich plasma were prepared from the samples with various growths concentration factors.
Researchers found that the concentration of the main growth factors were higher in the platelet-rich clot than the platelet-poor clot. The in vitro treatment of ACL cells with platelet-rich clot releasate resulted in a significant increase in cell number, and the total collagen production by the platelet-rich clot releasate-treated cells was significantly higher because of the enhanced cell proliferation.
There was no significant effect of the platelet-rich clot releasate treatment on gene expression for type-I collagen. However, type-III collagen was significantly enhanced, according to the report.
Read the abstract for "Effects of Autologous Platelet-Rich Plasma on Cell Viability and Collagen Synthesis in Injured Human Anterior Cruciate Ligament."
Read other coverage on sports medicine studies:
- Study Shows ACI Treatment Outcomes Similar Between Older and Younger Patients
- Study: Osteochondral Grafts May Be Safe for Young Knee Replacement Patients
- Study: PRFM Makes Little Long-Term Difference When Performing Arthroscopic Rotator Cuff Repair