Researchers identified a new target spinal cathespin G, for pain control in patients who exhibit chronic pain post-surgery. In the study, researchers evaluated the association between CTSG gene polymorphisms and the risk of chronic postsurgical pain in 1,152 patients, according to HCP Live.
Here are four notes:
1. The findings revealed 21.4 percent of the patients reported chronic postsurgical pain at a 12-month follow-up.
2. Researcher hypothesized blocking CTSG would reduce spinal cord inflammation and the results from the study suggest targeting proteases may indicate a new approach to regulate conceptive transmission in the spinal cord.
3. Male patients and patients under the age of 65 had a higher risk for chronic postsurgical pain. Researchers wrote, "Patients reporting severe pain early after surgery also tended to develop chronic postsurgical pain, but this did not reach statistical significance in our multivariate model."
4. The findings indicate CTSG can serve as a potential for chronic pain intervention and preoperative determination of CTSG gene polymorphisms may facilitate perioperative physicians to devise a plan to prevent chronic postsurgical pain.
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