Study: Matrix-induced autologous chondrocyte implantation encouraging for knee cartilage defects: 6 key notes

Orthopedic

A study published in The American Journal of Sports Medicine found matrix-induced autologous chondrocyte implantation treatment for knee cartilage defects yields "encouraging" outcomes.

Researchers conducted a randomized control trial examining 37 knees randomly allocated to either an eight week-return to weightbearing procedure or an accelerated six week program. Researchers evaluated the patients preoperatively and at one, two, three, six, 12 and 24 month visits. They used an MRI to gauge the quality and quantity of repair tissue and to calculate an MRI composite score.

 

Here's what they found.

 

1. Researchers observed significant improvements in all subjective tests including knee flexion and extension, six-minute capacity, peak knee extensor torque and knee extensor limb symmetry indices.

 

2. Knee flexor limb symmetry indices were above 100 percent for both groups at 12 months and 24 months. LSI tests for knee extensors were at 93.7 percent the eight week group and 87.5 percent for the six week group.

 

3. MRI composite scores and pertinent graft parameters improved over time with the six week group showing superior results at 24 months.

 

4. The six week group also demonstrated "good to excellent" infill at 24 months, compared to only 83 percent of the eight week group.

 

5. Two patients in the eight week group had a graft failure.

 

6. Eighty-three percent of the eight week group and 88 percent of the six week group were satisfied with their MACI surgery.

 

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